The serpent, the woman, and Adam sinned against God in Genesis 3:1-8. In Genesis 3:16, God passes sentence on the woman for her sin.
Matthew Henry wrote,
If man had not sinned, he would always have ruled with wisdom and love; and, if the woman had not sinned, she would always have obeyed with humility and meekness; and then the dominion would have been no grievance: but our own sin and folly make our yoke heavy.
Click HERE to read more on how sin brought a curse upon this first marital relationship.